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Researchers monitoring GI adverse events should collect data on meal patterns to differentiate compound-related GI effects from dietary confounders, particularly during the first 812 weeks of dose escalation when GI adverse events are most frequent

Consult your doctor before receiving the medicine

All authors approved the final version of the manuscript

Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents

This inspired us to hypothesize that inhibition of cholesterol biosynthesis branch of the mevalonate pathway may result in a concomitant shift of the metabolic flux to CoQ10 synthesis