This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction
Yue, Z., Bernardi, A., Li, C., Mironenko, A
That calcium signal is necessary for normal brain function, but excessive NMDAR activity creates excitatory pressure
There is a need for greater transparency and alignment in how weight management RCTs are designed, conducted, and reported to help different stakeholders (e.g., clinicians, regulatory bodies, prescribers, patients, payers, and guideline developers) understand how estimated treatment effects should be interpreted
Face and body
10.1038/onc.2010.640 44 GriesmannH.DrexelC.MilosevicN.SiposB.RosendahlJ.GressT