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Quite often though, a patient with B12 deficiency experiences symptoms getting worse before better when treatment with B12 injections start -so it can take a while to feel improvements

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Kostovski, L.S

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However, although p K a values for protein persulfides have not been reported so far, it is likely that the protein environment is able to tune the acidity of the persulfide as well as the acidity of the thiol, leading us to sound a note of caution against generalizations

Metallostasis is tightly orchestrated by upstream sentinels, metallosensors, specialized proteins or RNAs specific for a cognate metal that detects the bioavailability of that metal in the cell, and by doing so, control the expression of genes that encode other players in the metallostasis network (Figure 1)