The answer isnt as clear cut as you might imagine, suggests endocrinologist Caroline Messer, M.D
Circulation 148 , 16061635 (2023)
Effectiveness and evidence The strongest, most reproducible evidence for weight loss comes from prescription injectable GLP-1 therapies like semaglutide and tirzepatide, with multiple large randomized trials showing significant weight reduction and metabolic benefits
Additionally, the Wegovy pill has a much higher dose of semaglutide than the Ozempic pill (25 mg max versus 9 mg max, respectively)
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Medications that may be effective against nausea and diarrhea are antiemetic drugs, although evidence is limited: Benadryl, Bonine, Phenergan, Dramamine, Gravol