ada standards of care 2025 obesity pharmacotherapy glp-1 Concise Clinical Guidance: An ACC Expert Consensus Statement on Medical Weight Management for Optimization Cardiovascular Health: A Report of the American College of Cardiology Solution Set Oversight Committee New GLP-1 Guidelines for Type

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25 In the light of the current focus on cardiovascular safety of weight-loss drugs, 28, 29 the favorable effect on cardiovascular risk factors in the current trial seems promising

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In its preclinical pitch deck, ASC35 outperformed once-weekly tirzepatide by about 71% in diet-induced obese mice and showed a half-life roughly six times longer than tirzepatide in non-human primates

6 The durability of this protection was reinforced in 2023 when a high-profile Inter Partes Review (IPR) challenge filed by Mylan (now Viatris) against the 343 patent failed