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Research published in PubMed Central explains that transdermal absorption is generally effective only for small molecules

KD is also finding applications in reducing obesity and treating insulin resistance, type 2 diabetes, neurodegenerative diseases, and cardiovascular disorders

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There are also risks that come with substantial weight loss, Legro said

The clinical decision is which molecule does the most work for a given skin presentation, and how to sequence it within the broader skincare routine