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Thus, higher levels of sST2 are associated with increased myocardial fibrosis, adverse cardiac remodelling and worse cardiovascular outcomes ( Table 1 ).54 In HFpEF, sST2 levels have been associated with proinflammatory comorbidities, right ventricular (RV) pressure overload and dysfunction, and systemic congestion, but not with LV geometry or function

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Activation of PXR induces the expression of UGT1A1 the enzyme responsible for bilirubin glucuronidationas well as efflux transporters such as MRP2, enhancing bilirubin clearance from the liver