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Their use, however, is based on empirical evidence

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Another study comparing continuous versus interrupted GLP-1 therapy found that individuals who maintained treatment experienced sustained weight loss and stable appetite control, while those who paused therapy showed rapid appetite rebound and weight cycling

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Human islet histology Human islets were incubated overnight in medium plus 11 mM glucose 100 nM agonist prior to transfer to 4 C to arrest endocytosis and labeling with 1 M exendin-FITC, PFA fixation, 70% ethanol dehydration and suspension in 4% agarose small plugs