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Aggressive mixing can denature peptide chains and reduce potency

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GLP-1 receptor agonists have established effects on satiety and gastric emptying, while emerging evidence suggests effects on reward-related signaling relevant to loss-of-control eating

Por otro lado, la unin del GLP-1 con su receptor en la CBP tendra un efecto directo sobre la secrecin de insulina, potenciando las dos fases de secrecin de insulina y estimulando la transcripcin del gen y la traduccin del ARNm, incrementando as la biosntesis de proinsulina 25,26

Hsieh et al

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