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These devices are designed for patient convenience, requiring minimal training for self-administration

Acknowledgements We appreciate the participants and their families, and all academic personnel of the Al-Zahra Hospital, Isfahan, Iran for their kind cooperation

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FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4p53 protein interaction [1] [2]

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These hormones cause an increase in proliferation of skin cells and sebum production, leading to acne