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The area postrema and nucleus tractus solitarius receive vagal afferent signals from the gastrointestinal tract about nutrient status and gastric distension

Genetic ablation of GLP-1Rs in alpha cells results in glucose intolerance in vivo and suppression of glucagon secretion in isolated islets at low glucose concentrations [56]

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However, sustained losses of 2 to 3 pounds per week or more may increase the risk of muscle loss and rebound weight gain