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How tirzepatide works: Activates GLP-1 and GIP pathways Enhances insulin response Strongly suppresses appetite Improves energy metabolism Benefits of tirzepatide include: Greater weight loss potential compared to GLP-1 alone Improved blood sugar regulation Enhanced fat metabolism Long-lasting appetite control Many patients who do not respond fully to semaglutide may benefit from tirzepatide due to its dual mechanism

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Among 710 patients with type 2 diabetes, there were 17 cases of NAION in patients prescribed semaglutide (the scientific name of both drugs)

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Common gastrointestinal side effects include: Nausea and vomiting (affecting 1540% of patients, depending on the specific medication and dose) [13] [16] Diarrhoea (reported in 1030% of patients) Constipation (affecting 1020% of patients) Abdominal pain and discomfort Reduced appetite and early satiety Dyspepsia and gastro-oesophageal reflux symptoms These effects are generally dose-dependent and tend to improve over time as the body adjusts to the medication