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You should not take semaglutide if you are allergic to it or if you have conditions, such as: Stomach or intestinal disorder Kidney disease Pancreatitis Retinopathy (eye problems caused by diabetes) Diabetic ketoacidosis Family or personal history of thyroid cancer Multiple endocrine neoplasia type 2 (tumors in your glands) Pregnancy Side Effects of Semaglutide Semaglutide may cause side effects, such as: Diarrhea Nausea Vomiting Heartburn Burping Stomach pain Constipation Headache Low blood sugar in patients with type 2 diabetes Flatulence (gas buildup) Indigestion Other Weight Loss Management Topics