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Discussion at the American Heart Association session underscored the stakes of such decisions, as it was noted that an estimated 6.6 million American adults meet the inclusion criteria for the SELECT trial

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Stopping therapy without guidance risks rapid appetite return and weight regain

Humans responded similarly

Results announced in September 2025 and published in The Lancet in February 2026 demonstrated orforglipron's superiority over oral semaglutide on both HbA1c reduction (approximately 2.2 vs 1.4 percentage points) and weight loss (approximately 9.2% vs 5.3%)

Insurance coverage Your insurance may or may not cover GLP-1 medications