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BCL3 in Tcells displayed positive residuals, indicating higher unspliced mRNA levels than predictedconsistent with transcriptional bursts or delayed splicing during late differentiation

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From a clinical perspective, these findings underscore the value of exploring interventions that modulate and support oxidative stress pathwaysparticularly those relative to glutathione synthesis or recyclingas adjunctive strategies for managing treatment-resistant depression

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PBH was defined as a blood glucose level of 3.1 mmol/L after MMT

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Before the experiment, the cells were loaded with 0.2% Fluo-4 AM, which was dissolved in HEPES-buffered Hanks Balanced Salt Solution (HBSS, Thermofisher) containing 1 mM CaCl2, 1 mM MgCl2, and 0.5% probenecid (Thermofisher) for one hour

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