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doi: 10.1089/ars.2011.4145 117 TangCLiSZhangKLiJHanYZhanTet al

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Consistent with earlier studies, our data confirm that treatment with ALC was remarkably well tolerated with no treatment-related serious adverse event requiring treatment interruption and/or patient withdrawal

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In the hypothalamus, GLP-1R activation in the arcuate nucleus and area postrema suppresses appetite by enhancing POMC/CART neuron firing and inhibiting NPY/AgRP orexigenic signaling

Merck 2006