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Rather than moving to the next dose tier at 4 weeks, they hold each dose for 6 to 8 weeks before escalating

Then, tissue fragments were transferred to a conical tube with digestion buffer (PB, 2.5 mM glucose, 2.5 mg/g of Type I collagenase and 0.1% FFA-free BSA) and incubated for 20 min at 37 C on a bath shaker