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Affecting approximately 20% of children and up to 10% of adults worldwide (2), AD often manifests at birth or within the first years of life (3), with the majority of cases presenting before the age of two

Koburger T, Below H, Dornquast T, Kramer A

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Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help right away in the event of a known or suspected overdose [see PRECAUTIONS, Information for Patients and/or Caregivers]

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