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Table S2: Certainty of Evidence Table Author Contributions: All authors have read and agreed to the published version of the manuscript

Studies of medication switching show: 80-90% of patients tolerate the switch well 10-20% experience increased side effects requiring dose adjustment Weight loss typically continues after initial adjustment period Switching from semaglutide to tirzepatide often results in additional weight loss Important Considerations: Insurance and Cost: If switching due to insurance changes, verify coverage before stopping current medication

Circulation 149 , 450462 (2024)

This is generally not something you can control with brand-name products since the manufacturer handles formulation

Metformin is available as an affordable generic medication, costing as low as $10 for a 30-day supply, while Ozempic costs approximately $1,029 per month

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