However, they emphasized that no direct clinical cause-and-effect relationship has been proven
those who did not receive any intervention
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33 , LPS upregulated the expression of markers of neuronal activation including Bdnf , Sv2c and Vgf as well as Pdyn, a neuropeptide which modulates the inflammatory response ( Fig
While these findings should be interpreted with appropriate cautionthe study included only individuals with obesity (BMI 30 kg/m), and larger, more diverse trials are neededthey raise an important question