If you want the biology the literature predicts, you need a delivery method that bypasses the stratum corneum
Choosing the Right Vitamin B12 Supplement Not all supplements are created equal
All you have to do first before choosing one from the shelf is look for the ingredients used in the product
For instance, while agents such as L-carnosine, omega-3 fatty acids, methyl-B12, and coenzyme Q10 demonstrated inconsistent or limited improvements in specific symptom domains (e.g., sleep disturbances, social cognition, gastrointestinal symptoms), others such as NAC and SFN revealed more consistent clinical benefits
Plant Physiol 138:744756
The reconstituted solution at standard 3mL BAC water gives ~16.67mg/mL BPC-157 and ~3.33mg/mL each of TB-500, KPV, and GHK-Cu