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Phase 3: Continued escalation (weeks 9 through 12) Dose: 1.0 mg once weekly At 1 mg, the appetite effects become pronounced for most people
Also, a small cross-sectional study of 36 women with PCOS noted no changes in depression scores associated with liraglutide use over 6 months 204 , while another reported worsening depressive symptoms, which correlated with higher perceived stress scores, in 43 exenatide users with diabetes and obesity against non-users at 3 months 205
In terms of safety and tolerability, the adverse events were primarily mild to moderate gastrointestinal reactions, with no reports of severe hypoglycemia or death
However, it can be difficult to maintain a sustainable weight loss
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