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Med., 53:477-498 (2002)

Third, many metabolic targets are involved in fundamental cellular processes, and the lack of tissue and cell-type specificity represents a major bottleneck for clinical translation

A small pilot study at Boston University even explored the combination of berberine with vitamin D3 and K2, showing potential benefits for bone health in postmenopausal women

Because it is water-soluble, excess is typically excreted through the kidneys rather than accumulating to toxic levels, making supplementation generally safe even at high therapeutic doses

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In a double-blind, crossover study of 12 older men, participants consumed either 6 g/day of CIT or placebo for 6 days