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Maintenance strategies for semaglutide The STEP 4 trial demonstrated that patients who switched from semaglutide 2.4 mg to placebo regained an average of 11.6% of their body weight over the following 48 weeks, while those who continued semaglutide maintained their weight loss

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Randomized comparisons of bespoke microdosing schedules remain sparse

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Roughly 15-20% of people achieve exceptional results exceeding 25% weight loss

Retatrutide may eventually prove superior, but the evidence base is not yet mature enough for definitive comparison