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Writing of the manuscript or critical review of important intellectual content

The first embodiment of the present invention provides an improved process for the preparation of Semaglutide, comprising reacting (3-31) amino acid fragment of Semaglutide having the amino acid sequence Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu- Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly with PGi-His(PG)- Aib-OH to provide a peptide having amino acid sequence His-Aib-Glu-Gly-Thr-Phe-Thr- Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg- Gly-Arg-Gly and optionally converting the obtained compound to Semaglutide

Loss of HDL-mediated cholesterol efflux capacity has been found in patients with hyperhomocysteinemia (892), sepsis (893), psoriasis (894), SLE (895), RA (885,896), ESRD (897,898), and T2DM (899,900)

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The Science Behind Semaglutide Semaglutide mimics the bodys natural hormones, which are responsible for hunger control and digestion