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The treatment protocol failed in three cases, and was sub-optimal (50-75% response) in another case

Clinical Trials Demonstrating Reductions in Body Weight with GLP-1RAs Several clinical trials have reported that the effects described above resulted in larger reductions in body weight with GLP-1RA therapy compared with placebo in participants with obesity

That means there are no standardized, official dosing guidelines for obesity outcomes, and products sold in the market may not meet pharmaceutical-level quality controls

WES was also performed on plasma obtained prior to death from 4 patients (Supplementary Fig