After a recent tirzepatide dose escalation, the patient developed severe vomiting, metabolic derangements, sepsis physiology, and later GI bleeding, requiring coordinated management by endocrinology, gastroenterology, and cardiology.As GLP-1 use expands, careful dose titration, awareness of overlapping syndromes, and early multidisciplinary involvement are essential
Jul 13 2023;15(14)doi:10.3390/nu15143122
The mechanism of action of IGF-1 LR3 is discussed further on our dedicated page
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About 1 in 4 may regain some weight, but its uncommon for anyone to return to their highest weight
