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Metabolism slows, muscle mass may decline, and hormones shift, especially around perimenopause, menopause, or age-related testosterone changes

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25.2 Ephelide: note the hyperpigmentation of the basal layer of the epidermis

Extremely high temperatures have been shown to denature cytoskeletal proteins, leading to their abnormal distribution in the oocyte 12 , leading mitochondria to relocate to the cell periphery instead of maintaining a homogeneous distribution throughout the cytoplasm 67

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