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KH815 has been shown to produce a more potent antitumor effect than single TOPI inhibitor-TROP2-targeting ADCs as well as the ability to overcome drug resistance in preclinical cancer models, and is currently being investigated in a phase I clinical trial in patients with advanced solid tumors (NCT06885645) 237

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Study limitations include retrospective design, reliance on de-identified administrative data, inability to assess patient adherence, dosage, or causality, and residual confounding despite propensity score matching

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