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These drugs exert systemic effects that are crucial for a thorough understanding their safety profile, particularly in the context of obesity management

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(21) They found that semaglutide was associated with increased CTX-1 levels (p = .021) and reduced BMD at weight-bearing sites, including the lumbar spine (p = .007), total hip (p = .001), and tibia (p = .003)

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Effect of graded intraduodenal glucose infusions on the release and physiological action of gastric inhibitory polypeptide