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Amino acid metabolism has extremely extensive effects in cancer cells, including, but not limited to, (1) establishing amino acid pools as building blocks, especially the production of non-essential amino acids for protein biosynthesis, conversion to glucose, lipids, and precursors of nitrogen-containing metabolites, such as purines and pyrimidines for nucleic acid synthesis

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Since GSH plays a key role in oxidative stress suppression, ferroptosis suppression, and aldehyde detoxification, persistent or high consumption of tissue GSH may promote ferroptosis in ALDH2*2 individuals, suggesting crosstalk between aldehyde metabolism and ferroptosis pathways