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High-throughput screening in MADD cell lines has identified several lumichrome derivatives that restore mutant ETFDH activity at micromolar concentrations, validating the concept of pharmacological riboflavin agonists (76)

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These include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and specific 5-hydroxytryptamine antidepressants, as well as benzodiazepines (Zelek-Molik and Litwa, 2025)

Lexapro blocks that process, called reuptake, so serotonin stays in the space between nerve cells longer