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Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear factor-erythroid 2related factor 2 target genes, and show enhanced ethanol clearance, altered hepatic lipid profiles in favor of increased levels of polyunsaturated fatty acids and concordant changes in expression of genes associated with lipogenesis and fatty acid oxidation

Research shows Dihexa increases dendritic spine density by 40-50% in hippocampal neurons, with these new spines demonstrating functional characteristics of mature synapses including colocalization with presynaptic markers synapsin and VGLUT1, and generation of enhanced excitatory postsynaptic currents

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