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Child Psychiatry Hum

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Intermediates of the TCA cycle were also significantly decreased in biofilm lawns compared to suspended cultures, including alpha-ketoglutarate (FC = 0.07, p = 3.19 10 -3 ), succinate (FC = 0.08, p = 6.25 10 -6 ), pyruvate (FC = 0.22, p = 1.88 10 -3 ), and fumarate (FC = 0.32, p = 2.87 10 -2 )

Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors