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Cathepsin D drives the formation of hybrid insulin peptides relevant to the pathogenesis of type 1 diabetes

Curr Drug Targets 26(1):3358 Mazur A et al (2021) Nrf2 as a therapeutic target in ischemic stroke

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Melanotan 2 (MT2) is another synthetic analog of alpha-MSH, but it differs significantly from MT1 and alpha-MSH in terms of structure [5]: MT2 is a cyclic peptide consisting of seven amino acids, forming a ring due to a lactam bridge established through a linkage between the side-chain carboxyl group of aspartic acid at the second position and the side-chain amino group of the lysine residue at the seventh position

If we categorize DPP-4 inhibitors, there are three primary groups to consider

Pancreatitis Acute pancreatitis has occurred in patients treated with GLP-1 agonists, including tirzepatide