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When fed a HF-CTRL diet, WT and liver PSAT1 KO mice showed similar glucose tolerance (Fig

Lu S, Wang J, Chitsaz F, Derbyshire MK, Geer RC, Gonzales NR, et al

Samples were resuspended in 160 L EPPS buffer (200 mM, pH 8.0) using a probe sonicator (1 1015 pulses, power output 20%) and then digested with LysC (4 L of 0.5 g/L per sample, resuspended in HPLC grade water, Wako-chemicals, Fujifilm #125-05061) for 2 h at 37 C in a shaker incubator

Tirzepatide is FDA-approved and available as Mounjaro (T2D) and Zepbound (obesity)

But it turns out that is not the case

UA is considered the major circulating antioxidant and thus provides protection from oxidative stress and consequent damage