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Patients with GI sensitivity: While orforglipron's GI side effect profile is broadly similar to injectable GLP-1s, the daily oral dosing means the GI tract is exposed to the active compound on a different kinetic schedule than weekly injections

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Common, mild reactions: Serious risks (rare but real): When they are worth it: When they are not worth it: These options often give more predictable, longer-lasting results for skin tone and texture

M.HarveyK.GispertS.et al (2004)

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