Notably, the ASC-binding peptide CSWKYWFGEC selectively binds to decorin (DCN), a unique marker expressed on the ASC surface (Daquinag et al., 2017)
GR is also widely distributed and is believed to be primarily cytoplasmic, although at least in yeast an alternatively translated isoform is targeted to the mitochondria [54]
Nuciferine protects hyperandrogen-injured ovarian granulosa cells by inhibiting ferroptosis via SOX2-mediated activation of the SLC7A11/GPX4 axis
Metformin , the first-line type 2 diabetes drug and an AMPK activator, has cognitive data that are observational and inconsistent, and it lowers BDNF, a growth factor the brain relies on and that exercise raises, which is a reason for caution in a healthy brain
In this review, we summarize recent data on the regulation of mitochondrial GSH and its role in cell death and prevalent human diseases, such as cancer, fatty liver disease, and Alzheimers disease
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