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Mechanistically, CAFs promoted iron overload in NK cells and ferroptosis via (1) increase in FPN and hephaestin-mediated iron release to the TME, and (2) enhanced ferritinophagy via upregulation of NCOA4 in NK cells [58]

Weeks 5 through 8 (first escalation): Dose increases to the next level, still once daily

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41 There have also been case reports of pulmonary aspiration in patients taking GLP-1 receptor agonists who have undergone anaesthesia

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