are glp-1 biologics for Weight Loss and Diabetes Graphical presentation of the mechanism

Effects of non-covalent self-association on the subcutaneous absorption of a therapeutic peptide

By signaling through GLP-1R expressed in the reward and satiety areas of central nervous system, GLP-1RAs reduce caloric intake and result in 14 kg weight loss on average over several months

Furthermore, NHEJ-mediated knock-in, including HITI, supports the insertion of large DNA fragments (up to ~50 kb), making it an exceptionally powerful tool for in vivo genome editing therapies 12

2018;11(S 01):Trab722

Evidence is mixed

22 GLP-1RAS AND GLAUCOMA GLP-1Rs are found in neurons and glial cells located throughout the central nervous system, as well as in ganglion cells of the retina and optic nerve