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Most common side effects at 12mg (TRIUMPH-4): Nausea: 43.2% (vs 10.7% placebo) Diarrhoea: 33.1% (vs 13.4% placebo) Vomiting: 20.9% (vs 0% placebo) Constipation: 25.0% (vs 8.7% placebo) The majority were moderate in severity, mostly during dose escalation, and reduced once participants stabilised on their maintenance dose

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A volume of 4-NPG (final concentration of 1 mM) was added to the reaction and decrease in absorbance at 305 nm was recorded on an Envision multilabel plate reader (Perkin Elmer)

In females, IGF-1 was inversely associated with the abdominal sagittal diameter (SagD) and with the visceral AT (r = -.41, P = .006)