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These modifications, aiming to improve the safety profile and ease of manufacture, have resulted in reduced immunogenicity

They cause oxidative stress

Frequency, signs and symptoms, and criteria adopted for long COVID-19: A systematic review

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Mechanistically, FSH vaccination treatment inhibited lipid biosynthesis by inactivating PPAR adipogenic signaling pathway and simultaneously enhancing adipocyte thermogenesis via upregulating UCP1 (uncoupling protein 1) expression in both visceral and subcutaneous adipose tissues (74)