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YX: Writing review & editing

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Pro-inflammatory cytokines can inhibit tight-junction protein production and enhance transcytosis in brain endothelial cells, allowing soluble mediators and peripheral immune cells (monocytes, T cells) to enter the parenchyma [92]

Promotes hyperplasia (creation of new muscle fibers) Accelerates muscle repair and recovery post-exercise Enhances nutrient transport and cellular growth signaling IGF1 induces proliferation and differentiation of muscle satellite cells, enabling hypertrophic adaptations in response to overload. Adams et al., Journal of Applied Physiology Muscle Preservation Post-Cycle IGF1 LR3 helps preserve lean mass during post-cycle therapy (PCT) or caloric restriction

Hauser RA, Hsu A, Kell S, Espay AJ, Sethi K, Stacy M, et al

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