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In the Bridge-TIMI 73a study involving patients with hypertriglyceridemia and the BALANCE study focusing on patients with familial chylomicronemia syndrome, Olezarsen significantly lowered plasma triglyceride levels without causing major safety issues

Consistently, we also found an association of genetically predicted l-carnitine and its isoform, acetyl-carnitine, with higher triglycerides and lower HDL-cholesterol

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doi: 10.1542/peds.2013-2336, PMID: [DOI] [PubMed] [Google Scholar] 49.Volpe JJ