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For example, people who are experiencing loss of kidney function due to diabetes may find that high strength B12 supplementation can cause the loss of function to speed up (House et al., 2010), and high dose supplements of B12 may also increase the risk of colon cancer in older people

Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Collagen Loss and Skin Breakdown As we age, collagen production slows and skin becomes thinner, looser, and more fragile

Chen Sci Rep 2025;15:18063

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It is not a substitute for the official label, pharmacist counseling, prescriber instructions, or medical advice