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380 The Ni/Co specificity of InrS over Cu I and Zn II has been evaluated both in vivo and In vitro , revealing that the affinity of InrS for these other transition metal ions is sufficiently low, i.e., an insufficiently negative G relative to Ni II (Figure 8), which prevents induction of the expression of genes encoding Ni II transporters as a result of mismetalation (Figure 12D)

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The peptide counteracted picrotoxin (non-competitive GABA receptor Cl channel blocker), isoniazid (inhibitor of glutamic acid decarboxylase and GABA synthesis), and bicuculline (GABA-A antagonist), all through dose-dependent protective effects without producing behavioral changes when administered alone

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