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Yes, over-the-counter topical numbing creams (like those containing lidocaine) can be used

This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)

However, body image and body size are not the same thing

The findings, which were presented over the weekend at ENDO 2026, the Endocrine Society's annual meeting, were based on an analysis of health records from more than 42,000 adults who were already taking at least two types of blood pressure medications when they began treatment with GLP-1 drugs such as semaglutide, tirzepatide or liraglutide

Please see the full Prescribing Information for complete safety information

A very small percentage of patients get pancreatitis, that's one of the major side effects