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Reports of skin irritation and blisters with some patch products add safety concerns to the effectiveness questions

The proportion of total fat mass (SE) was reduced from an overall baseline of 37.6% by 1.4%-point (0.39) and 1.2%-point (0.35) with semaglutide and canagliflozin, respectively (ETD 0.21 [95% CI 1.26, 0.84]) (Fig

0.1%, the authors noted

In so doing, it significantly reduces patients appetites causing them to lose significant amounts of weight

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