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When Ozempic activates GLP-1 receptors in the gastrointestinal tract, it can alter the balance of fluid absorption and secretion, potentially leading to looser or more frequent stools

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However, the relationship between insulin therapy and platelet function remains controversial

For the efficacy estimand, the highest dose of tirzepatide led to an HbA1c reduction of 2.58% and reduced body weight by 11.7 kg compared with insulin glargine (mean HbA1c reduction of 1.44% and mean weight gain of 1.9 kg) at 52 weeks