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Beyond these indications, there is evidence suggesting that L-Carnitine may be beneficial in the management of chronic heart failure and angina by improving exercise tolerance and reducing the risk of myocardial ischemia

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15 Unfortunately, they also cause most frequently lethal drug toxicity such as gastrointestinal haemorrhage

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If HORIZON confirms major adverse cardiovascular events (MACE) reduction, pelacarsen could redefine risk stratification and treatment in atherosclerotic disease